Drug intelligence / Profile preview

tailored guizhi decoction

Development stage
Unknown
Lead developer
Ohsugi Pharmaceutical
Administration
Oral
01

Overview

Tailored Guizhi Decoction is a modified traditional Chinese herbal formula based on the classic Guizhi Decoction (Cinnamon Twig Decoction). It is customized for individual patients, often by adding or substituting herbs to address specific symptoms or conditions. In recent clinical studies, a tailored version of this decoction has been used as an adjunct therapy for traumatic anosmia (loss of smell following head trauma), typically in combination with olfactory training. The mechanism of action is not fully elucidated but is believed to involve modulation of immune and inflammatory responses, neuroprotection, and possible support for neural regeneration through the combined effects of its herbal constituents. The formula's composition may vary depending on patient needs but generally includes core ingredients such as Cinnamomum cassia (Gui Zhi) along with other herbs selected according to traditional Chinese medicine principles[1][3][4][7]. There are no major pharmaceutical companies associated with its development; it is prepared by practitioners or local manufacturers specializing in Chinese herbal medicine.

Other names
tailored Guizhi decoction
02

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)IL-6 (Interleukin 6)MAPK3 (Mitogen-activated protein kinase 1)

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