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TAK-105-b is a **peptide agonist** in development by Takeda for the potential treatment of **nausea and vomiting**. It is administered by subcutaneous injection and is a variant/formulation within the TAK-105 program, which includes TAK-105-a as well. The precise molecular target and mechanism of action of TAK-105-b are not publicly disclosed, but it is classified as a peptide/oligonucleotide agonist. The primary indication being studied is nausea and vomiting in healthy adults, with phase I clinical trials focused on safety, tolerability, pharmacokinetics, and maximum tolerated dose. Currently, TAK-105-b has not reached a phase beyond initial human safety studies[1][5][7].
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