talampicillin

Talampicillin is an orally administered beta-lactam antibiotic from the penicillin family. It is a prodrug of ampicillin, designed to improve oral absorption and bioavailability compared to ampicillin itself. After oral administration, it is rapidly absorbed and hydrolyzed by tissue esterases in the intestinal wall to release active ampicillin and 2-hydroxymethyl-benzoic acid; no unchanged talampicillin appears in peripheral blood. Its mechanism of action involves inhibition of bacterial cell wall synthesis by targeting penicillin-binding proteins (PBPs), leading to bacterial cell lysis and death. Talampicillin was developed as an acid-stable alternative for oral use but has not been approved by the FDA for use in the United States[1][4][5][6][7].

Brand names

Talpen

Other names

talampicilinatalampicillinetalampicillinumampicillin, phthalidylphthalidyl ampicillinhydrochloride, talampicillintalampicillin hydrochloride