talaporfin sodium

Talaporfin sodium is a small molecule photosensitizer derived from chlorophyll (specifically a derivative of chlorin e6 conjugated with L-aspartic acid). It is used in photodynamic therapy (PDT) for the treatment of various cancers. Upon intravenous administration and subsequent activation by red light (typically at 664 nm), talaporfin sodium generates singlet oxygen and other reactive oxygen species that induce free radical-mediated cell death in targeted tumor tissues. This dual action results in direct cancer cell killing and vascular shutdown within tumors. Talaporfin sodium has been approved in Japan for PDT of lung cancer under the brand name Laserphyrin and has also been investigated for use in glioblastoma, bile duct carcinoma, esophageal cancer recurrence after chemoradiotherapy or radiotherapy failure, port-wine stain birthmarks, benign prostatic hyperplasia (BPH), and other solid tumors[1][5][7].

Brand names

Laserphyrin

Other names

NPe6NPe-6NPe 6mono-L-aspartyl chlorin e6monoaspartyl chlorin e6N-aspartyl chlorin e6N-aspartylchlorin e6aspartyl chlorin