talsaclidine

Talsaclidine is a synthetic small molecule that acts as a non-selective muscarinic acetylcholine receptor agonist. It functions as a full agonist at the M1 subtype and as a partial agonist at the M2 and M3 subtypes of muscarinic receptors. Talsaclidine was developed primarily for the treatment of Alzheimer's disease, aiming to enhance cholinergic neurotransmission in the brain. However, clinical trials demonstrated only modest or poor efficacy in both animal models and humans, with its development further limited by dose-dependent side effects such as increased heart rate and blood pressure, excessive salivation, urinary frequency and burning upon urination, increased lacrimation and nasal secretion, abnormal accommodation (vision changes), gastrointestinal disturbances (heartburn, cramps, nausea), excessive sweating, palpitations, among others[9][7][10]. The drug belongs to the quinuclidine class of organic compounds.

Other names

talsaclidine fumarate