talsupram

Talsupram is a selective norepinephrine reuptake inhibitor (NRI) that was investigated as an antidepressant in the 1960s and 1970s but was never marketed. It acts by inhibiting the norepinephrine transporter (NET), thereby increasing synaptic concentrations of norepinephrine. Talsupram is structurally related to citalopram, a selective serotonin reuptake inhibitor (SSRI), and talopram, another NRI. Preclinical studies have also explored its analgesic effects in neuropathic pain models, where it demonstrated significant anti-hyperalgesic activity at supraspinal levels compared to other antidepressants[1][2][3][4][5].

Other names

talsupram [INN]