taltirelin

Taltirelin is a synthetic analog of thyrotropin-releasing hormone (TRH) that acts as a superagonist at the TRH receptor. It mimics the physiological actions of TRH but has a much longer half-life and duration of effect, with little development of tolerance upon prolonged dosing. Taltirelin activates neural cells by binding to TRH receptors, promoting the release and metabolic turnover of neurotransmitters such as acetylcholine, dopamine, noradrenaline, and serotonin. It also exhibits neurotrophic factor-like activity and enhances local glucose metabolism in the central nervous system. Clinically, taltirelin is approved in Japan for improving ataxia in patients with spinocerebellar degeneration (spinocerebellar ataxia) and has been studied for other neurodegenerative disorders such as spinal muscular atrophy and Parkinson’s disease. The drug demonstrates nootropic, neuroprotective, and analgesic effects[1][2][3][4][5][6][7][8].

Brand names

CeredistTALTIRELIN OD Tablets "SAWAI"Taltirelin Tablets "JG"

Other names

taltirelina(1-methyl-4,5-dihydroorotyl)-histidyl-prolinamide