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Drug intelligence / Profile preview
tamarindus indica fruit pulp extract
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tamarindus indica fruit pulp extract is a botanical extract derived from the fruit of the tamarind tree, currently being investigated for its neuroprotective potential. The extract contains a complex mixture of bioactive compounds, including phenolics, flavonoids, tannins, and steroids. Its mechanism of action involves the modulation of the cholinergic system through the inhibition of acetylcholinesterase (AChE) activity, alongside potent antioxidant and anti-inflammatory effects, such as the reduction of pro-inflammatory cytokines. Preclinical studies in rat models of acrylonitrile-induced neurodegeneration suggest that the extract can attenuate oxidative stress and neuronal loss, positioning it as a potential therapeutic candidate for neurodegenerative conditions like Parkinson's disease.
- Other names
- tamarind fruit pulp extracttamarind extract
02
Targets
AcetylcholinesteraseHMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)NOS2 (Nitric Oxide Synthase 2)
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