Drug intelligence / Profile preview

tamarindus indica fruit pulp extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Tamarindus indica fruit pulp extract is a botanical extract derived from the fruit of the tamarind tree, currently being investigated for its neuroprotective potential. The extract contains a complex mixture of bioactive compounds, including phenolics, flavonoids, tannins, and steroids. Its mechanism of action involves the modulation of the cholinergic system through the inhibition of acetylcholinesterase (AChE) activity, alongside potent antioxidant and anti-inflammatory effects, such as the reduction of pro-inflammatory cytokines. Preclinical studies in rat models of acrylonitrile-induced neurodegeneration suggest that the extract can attenuate oxidative stress and neuronal loss, positioning it as a potential therapeutic candidate for neurodegenerative conditions like Parkinson's disease.

Other names
tamarind fruit pulp extracttamarind extract
02

Targets

NR1H3 (Liver X receptor beta)AcetylcholinesteraseHMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)NOS2 (Nitric Oxide Synthase 2)

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