Drug intelligence / Profile preview

tamarindus indica pulp extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Tamarindus indica pulp extract refers specifically to extract prepared from the fruit pulp of the tamarind tree (Tamarindus indica), a leguminous tropical plant widely used in both cuisine and traditional medicine. The pulp extract contains diverse phytochemicals including organic acids (notably tartaric acid), various phenolic compounds, flavonoids, glycosides, saponins, alkaloids, tannins, and essential nutrients such as vitamins and minerals[2][6][4][8]. **Mechanism of Action:** The extract demonstrates multiple pharmacological effects, featuring notable anti-inflammatory, antioxidant, analgesic, hypolipidemic, and mild antimicrobial activities[1][3][7][9]. Mechanistically, the anti-inflammatory activity is attributed to inhibition of cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), 5-lipoxygenase biosynthesis, tumor necrosis factor alpha (TNF-α), and potential activation of opioidergic mechanisms[1]. The hypolipidemic effect appears to involve modulation of hepatic lipid metabolism via LXR/RXR activation and reduction of cholesterol/triglyceride levels[3][7]. The extract also inhibits α-amylase enzyme activity with possible implications in glycemic control[6]. **Primary Indications:** Traditionally, it is used for pain, inflammation, fever, constipation (as a laxative), digestive disturbances, and as a supportive intervention for lipid disorders and cardiovascular risk[1][3][5][7][9]. **Development and Use:** Its use remains largely within traditional, dietary supplement, and botanical product contexts; it is not an approved pharmaceutical.

Other names
tamarind fruit pulp extracttamarind pulp extracttamarind extractTamarindus indica fruit pulp extract
02

Targets

ALOX12 (Arachidonate 12-lipoxygenase, 12S type)MOR (Mu opioid receptor)TNFA (Tumor necrosis factor alpha (soluble))PTGS2 (Prostaglandin-Endoperoxide Synthase 2)AMY (Pancreatic alpha-amylase)NOS2 (Nitric Oxide Synthase 2)NR1H3 (Liver X receptor beta)

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