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Drug intelligence / Profile preview
Tamarixetin
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Intraperitoneal (for Experimental Studies), Oral (potential)
01
Overview
Tamarixetin is a naturally occurring flavonoid derived from quercetin. It exhibits various biological activities, including anti-inflammatory, antioxidant, and anticancer properties. Tamarixetin has shown potential in treating conditions such as ischemic stroke, colorectal cancer, and liver injury. It acts by inhibiting pathways like the NLRP3 inflammasome and modulating signaling pathways such as NF-κB and WNT3A/β-catenin. Tamarixetin also protects chondrocytes from IL-1β-induced cellular stress and has been explored for its chondroprotective effects against osteoarthritis.
- Other names
- Chiosmethin4'-Methoxyquercetin
02
Targets
NOX2 (NADPH oxidase 2)NF-κBNLRP3 (Nod-like receptor family pyrin domain-containing protein 3)NOX4 (NADPH oxidase 4)
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