Drug intelligence / Profile preview

tamsulosin

Development stage
Approved
Lead developer
Astellas Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Tamsulosin is a selective alpha-1A and alpha-1B adrenergic receptor antagonist primarily used to treat the symptoms of benign prostatic hyperplasia (BPH), such as difficulty urinating and urinary frequency in men[2][3][5]. By selectively blocking alpha-1A adrenergic receptors in the smooth muscle of the prostate and bladder neck—where these receptors are most prevalent—tamsulosin relaxes these muscles to improve urine flow and reduce BPH symptoms[2][7]. Its selectivity for alpha-1A over alpha-1B receptors results in fewer cardiovascular side effects compared to less selective agents[7]. Tamsulosin may also be used off-label for conditions like ureteral stones and prostatitis[5]. Developed by Astellas.

Brand names
FlomaxFlomaxtraHarnal DOmnicOmixPradifCositam XLFlomax ReliefLosinate MROmsula MRTamfrex XLTamsumac MRTamurex MRBetamsalContiflo XLMaxrinMecirOmexelOmiproRanomaxSaloverSecotexStronazonTamsactTamsolTamsulEbunat-0.4Ebunat0.4Ebunat 0.4Urotril-0.4Urotril0.4Urotril 0.4Urotril Plus
Other names
tamsulosin hydrochloride
02

Targets

ADRA1D (α1D)ADRA1A (α1A)ADRA1B (α1B)

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