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Tan Chuan Dripping Pills
- Development stage
- Unknown
- Lead developer
- Hainan Haochuang Pharmaceutical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Tan Chuan Dripping Pills is a traditional Chinese medicine (TCM) formulation developed by Hainan Haochuang Pharmaceutical for the treatment of chronic bronchitis. The product is a dripping pill formulation containing active alkaloids, primarily matrine and oxymatrine, which are typically extracted from *Sophora* species such as *Sophora flavescens*. These alkaloids possess anti-inflammatory, antitussive, and expectorant properties, making them effective in reducing phlegm and relieving cough and asthma-like symptoms. In clinical trials, the dripping pill formulation has been evaluated for bioequivalence against traditional Tan Chuan tablets, with pharmacokinetic assessments focusing on the absorption and disposition of matrine and oxymatrine. The drug is often administered in conjunction with Huangbo fruit oil (Vitex oil) soft capsules to enhance its therapeutic effect on the respiratory system.
- Brand names
- Tan Chuan Dripping Pills
- Other names
- Tan Chuan Di Wan痰喘滴丸
02
Targets
KOR (Kappa opioid receptor)
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