tandamine

Tandamine is a tricyclic compound developed in the 1970s as an antidepressant but never commercialized. It is structurally related to pirandamine and was investigated primarily for the treatment of depression. The drug acts as a selective norepinephrine reuptake inhibitor (NRI), with little or no serotonin potentiation or monoamine oxidase inhibition. Clinical studies suggested it could be beneficial for certain types of depression (notably "retarded depressions") and that it possessed anticholinergic activity leading to reduced appetite and sedation. Despite some clinical benefit and tolerability in trials with hospitalized depressed patients at doses from 75 to 200 mg orally per day, it was never marketed[5][7][2][4].

Other names

TandaminaTandaminum1-(2-(dimethylamino)ethyl)-9-ethyl-1,3,4,9-tetrahydro-1-methylthiopyrano(3,4-b)indole2-(9-ethyl-1-methyl-3,4-dihydrothiopyrano[3,4-b]indol-1-yl)-N,N-dimethylethanaminetandamine hydrochloride (+)-isomertandamine hydrochloride (+/-)-isomertandamine hydrochloride (-)-isomer