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Tangluoning plaster
- Development stage
- Unknown
- Lead developer
- Longhua Hospital Shanghai University of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Tangluoning plaster is a Traditional Chinese Medicine (TCM) topical formulation developed by Longhua Hospital affiliated with the Shanghai University of Traditional Chinese Medicine. It is specifically indicated for the treatment of diabetic peripheral neuropathy (DPN), a condition characterized in TCM as Xiaoke Bi syndrome. The plaster is designed to be applied to specific acupuncture points or affected areas to tonify Qi, nourish Yin, and activate blood circulation to unblock collaterals. Pharmacologically, it is thought to work by improving local microcirculation, increasing nerve conduction velocity, and reducing the expression of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), while potentially upregulating neurotrophic factors like Nerve Growth Factor (NGF). It serves as a non-invasive adjuvant therapy to standard glycemic control for managing neuropathic symptoms like pain, numbness, and coldness in the extremities.
- Brand names
- Tangluoning plaster
- Other names
- Tangluoning GaoTangluoning topical plasterTangluoning medicated plaster
02
Targets
ChoP (Phosphorylcholine)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)EIF2AK3 (Pkr-like endoplasmic reticulum kinase)
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