tangningtongluo

Tangningtongluo (TNTL) is a traditional Chinese medicine (TCM) formula composed of Herba Plantagins, kewoluoqu, Flos Lonicerae, and Herba Agrimoniae. It has been widely used in southwest China for decades as an alternative or adjunctive therapy for diabetes mellitus and prediabetes. The preparation is a pure plant-based hospital formulation authorized by the Guizhou Provincial Food and Drug Administration in 2014. Preclinical studies demonstrate that TNTL exerts hypoglycemic effects by reducing blood glucose levels, improving glucose tolerance, enhancing insulin sensitivity, repairing pancreatic tissue damage, regulating lipid metabolism disorders, and protecting liver function in diabetic animal models. Mechanistically, its action may involve upregulation of insulin receptor substrate-1 signaling pathways and modulation of endoplasmic reticulum stress/NF-κB signaling with reduction of inflammatory cytokines such as TNF-α, IL-6 and IL-1β[1][4][6][7][8]. Clinical trials have reached Phase 3 for indications including nonproliferative diabetic retinopathy[3].

Brand names

Tangningtongluo Tablet

Other names

Tangningtongluo formulaTangNing TongLuo Tablets