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tannic acid + calcium carbonate
- Development stage
- Preclinical
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intraarticular
01
Overview
TA + calcium carbonate is a research-stage multifunctional nanomedicine composed of tannic acid (TA) and calcium carbonate (CaCO3). It is typically synthesized via a biomineralization approach, often incorporating stabilizing polymers such as poly(ethylene glycol)-b-poly(glutamic acid) to form nanoparticles. The compound is designed to target the pathological microenvironment of inflammatory diseases, specifically addressing the elevated reactive oxygen species (ROS) levels and acidic conditions found in articular spaces. By neutralizing acidity and scavenging ROS, the nanomedicine reduces lipid peroxidation in M2 macrophages and decreases the production of pro-inflammatory factors. Research indicates potential therapeutic efficacy in treating rheumatoid arthritis and protecting chondrocytes from oxidative stress.
- Other names
- tannylated calcium carbonate
02
Targets
Mpro (3C-like proteinase of SARS-CoV-2)TMPRSS2 (Transmembrane protease serine 2)
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