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Tannquilynne
- Development stage
- Unknown
- Lead developer
- SyneuRx International
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tannquilynne is a small molecule D-amino acid oxidase (DAAO) inhibitor developed by SyneuRx International (Taiwan) Corp. for the treatment of dementia with psychosis and cognitive impairment associated with mild-to-moderate Alzheimer's disease. The drug works by inhibiting the DAAO enzyme, which is responsible for the metabolism of D-amino acids such as D-serine. By maintaining or increasing cellular levels of D-serine, a critical co-agonist of the N-methyl-D-aspartate (NMDA) receptor, Tannquilynne enhances glutamatergic neurotransmission. This mechanism is intended to improve cognitive function and alleviate psychotic symptoms in patients with dementia. Tannquilynne is described as having a well-known safety profile and human use history, and it has received FDA approval to proceed with Phase 2 clinical trials.
- Brand names
- Tannquilynne
02
Targets
DAO (D-amino-acid oxidase)
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