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tanshinone I

Development stage
Unknown
Modality
Small Molecules
01

Overview

Tanshinone I is a natural abietane diterpenoid quinone compound isolated from the roots of Salvia miltiorrhiza (Danshen), a traditional Chinese medicinal herb. It is classified as a small molecule and has demonstrated a wide range of biological activities, including anti-cancer, anti-inflammatory, and anticoronaviral effects. Mechanistically, tanshinone I has been shown to suppress growth and invasion of human cancer cells by regulating adhesion molecules such as ICAM‑1 and VCAM‑1. It also exhibits inhibitory effects on angiogenesis and cell proliferation in various preclinical models. While it is widely used in experimental research, its clinical development status remains largely investigational[1][2][3][6].

Other names
Tanshinon ITanshinone ATanshine ITanshinoneⅠTANSHINONE 1TANSHINONE1TANSHINONE-1Tanshinone lAKOS NCG1-0066Salvia quinone
02

Targets

ICAM1 (Intercellular Adhesion Molecule 1)VCAM1 (Vascular cell adhesion molecule 1)

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