Drug intelligence / Profile preview

taraxacum officinale pollen extract

Development stage
Unknown
Lead developer
Nelco Laboratories
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous, Intradermal, Percutaneous
01

Overview

Taraxacum officinale pollen extract is a biologic allergenic extract derived from the pollen of the common dandelion (*Taraxacum officinale*). First approved by the FDA in 1965, it is primarily utilized as a diagnostic tool in percutaneous (skin prick) or intradermal testing to identify individuals with hypersensitivity to dandelion pollen. In addition to its diagnostic role, the extract is used in allergen immunotherapy (hyposensitization) to treat allergic rhinitis, allergic conjunctivitis, or asthma triggered by dandelion exposure. The extract works by introducing specific allergens to the patient's immune system; for diagnosis, this triggers an immediate IgE-mediated mast cell degranulation resulting in a wheal-and-flare reaction, while for therapy, repeated subcutaneous administration aims to induce immunological tolerance and shift the immune response away from a Th2-mediated allergic profile.

Brand names
Greer Allergenic ExtractALK-Abello Allergenic Extract
Other names
Dandelion Pollen ExtractTaraxacum officinale extractDandelion Allergenic Extract
02

Targets

IgE (Immunoglobulin E)

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