Tarazepide

Tarazepide is a small molecule primarily known as a cholecystokinin 1 (CCK1) receptor antagonist, extensively utilized in research to investigate the regulation of pancreatic exocrine secretion and the involvement of CCK and vagal nerves in various physiological responses. It has been administered intravenously, intraduodenally, and intraperitoneally in animal studies. More recently, molecular docking screens have identified tarazepide as a potential inhibitor of inorganic pyrophosphatase 1 (PPA1), suggesting a possible repurposing for cancer medicine. A significant challenge with tarazepide is its poor solubility, which has led to investigations into novel formulations such as nanosuspensions for improved bioavailability, particularly for intravenous administration.