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Target A Bifunctional Degrader

Development stage: Preclinical
Lead developer: Pin Therapeutics
Modality: PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules

Overview

Target A Bifunctional Degrader is a proteolysis-targeting chimera (PROTAC) being developed by Pin Therapeutics in collaboration with GENOPHIN. The drug is designed to treat solid tumors by inducing the targeted protein degradation of an undisclosed protein, referred to as Target A. As a bifunctional degrader, the molecule likely consists of a ligand for the target protein connected via a linker to a ligand for an E3 ubiquitin ligase, facilitating the ubiquitination and subsequent proteasomal degradation of the target. The program is currently in the discovery stage of development.

Other names: Target A PROTAC

Targets

CRL4-CRBN (Cereblon-based E3 ubiquitin ligase complex)

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