TARP-2306

TARP-2306 (also known as [18F]TARP-2306 or 18F-Tarplify) is a high-affinity, selective positron emission tomography (PET) radioligand designed for the noninvasive quantification and mapping of transmembrane AMPA receptor regulatory protein gamma-8 (TARP-gamma8) expression in the living brain. Developed by researchers at Emory University, TARP-2306 binds with high affinity (Ki = 10.23 nM) to TARP-gamma8, an auxiliary subunit of AMPA-type glutamate receptors that is highly expressed in the hippocampus and plays a central role in synaptic plasticity and excitatory neurotransmission. Preclinical and translational studies in rodents, nonhuman primates, and humans demonstrate favorable brain kinetics, robust blood-brain barrier penetration, and regional specificity, highlighting its potential as a molecular imaging tool for investigating TARP-gamma8-related neuropathologies, such as epilepsy, and for therapeutic monitoring of TARP-gamma8-modulating interventions.

Other names

[18F]TARP-2306Tarplify