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TAS2R1 agonist (Amaro Therapeutics)

Development stage
Preclinical
Lead developer
Amaro Therapeutics
Modality
Small Molecules
Administration
Oral
01

Overview

This preclinical-stage small molecule agonist, developed by **Amaro Therapeutics**, targets the **TAS2R1** receptor, a member of the bitter taste receptor family. While traditionally associated with oral taste perception, TAS2R1 is an extra-oral G-protein coupled receptor (GPCR) found in various tissues where it functions as part of the body's nutrient-sensing network. By activating TAS2R1, the compound aims to modulate metabolic and inflammatory pathways to restore homeostasis. The program is currently being investigated for the treatment of metabolic dysfunction and age-related inflammatory conditions, including **obesity**, **type 2 diabetes**, **metabolic-associated steatohepatitis (MASH)**, and other age-linked inflammatory disorders.

Other names
TAS2R1 agonistTAS-2R1 agonistTAS 2R1 agonist
02

Targets

TAS2R1 (Taste receptor type 2 member 1)

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