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Tat-ELP-DOXO
- Development stage
- Unknown
- Lead developer
- University of Mississippi Medical Center
- Modality
- Peptide-Drug Conjugates → Peptide Conjugates → Peptides, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Tat-ELP-DOXO is a research-stage biopolymer-drug conjugate consisting of three components: the HIV Tat cell-penetrating peptide (CPP), which facilitates intracellular delivery by promoting uptake across cell membranes; an Elastin-like polypeptide (ELP), a thermally responsive biopolymer derived from mammalian elastin that passively accumulates in solid tumors and aggregates under hyperthermic conditions; and doxorubicin (DOXO), conjugated via an acid-sensitive (6-maleimidocaproyl)hydrazone linker to a terminal cysteine on the ELP. The active chemotherapeutic payload is doxorubicin, which intercalates into DNA and inhibits topoisomerase II. Tat-ELP-DOXO is designed to improve tumor-targeted delivery of doxorubicin using mild hyperthermia, thereby reducing systemic toxicity. It has been studied in preclinical models of breast cancer.
- Other names
- Tat-ELP-doxorubicin
02
Targets
TOP2A (DNA topoisomerase II)DNA
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