Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Tat-Hhi-ELP
- Development stage
- Preclinical
- Lead developer
- University of Mississippi Medical Center
- Modality
- Peptides, Recombinant Proteins and Enzymes
- Administration
- Parenteral, Intravenous
01
Overview
Tat-Hhi-ELP is a thermally responsive polypeptide conjugate designed to inhibit the Hedgehog (Hh) signaling pathway. Developed at the University of Mississippi Medical Center, the construct consists of a cell-penetrating peptide (Tat) and a Hedgehog-inhibitory peptide (Hhi) fused to an elastin-like polypeptide (ELP) biopolymer. The ELP component, derived from mammalian tropoelastin, undergoes a phase transition and aggregates at tumor sites in response to local hyperthermia, enabling targeted delivery. The Hhi peptide blocks the interaction of Sonic Hedgehog (Shh) ligand with the Patched-1 (PTCH1) receptor, thereby suppressing downstream Hh signaling and reducing GLI-1 transcription factor levels. Preclinical studies have demonstrated its efficacy in inhibiting the proliferation of breast cancer cells and targeting breast cancer stem cells.
- Other names
- Tat-Hhi-elastin-like biopolymerTat-Hhi-elastin-like polypeptide
02
Targets
PTCH1 (Patched 1 Protein)SHH (Sonic hedgehog)
Beyond the preview
Go deeper on Tat-Hhi-ELP.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Tat-Hhi-ELP.