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TATE-sNIR
- Development stage
- Preclinical
- Lead developer
- Helmholtz Munich
- Modality
- Peptides
- Administration
- Intravenous
01
Overview
SSTR2-sNIR probe (also known as TATE-sNIR) is a near-infrared (NIR) fluorescent imaging probe developed for precision fluorescence-guided surgery, particularly for the intraoperative visualization of meningiomas and other somatostatin receptor type 2 (SSTR2)-expressing tumors. The probe is synthesized by conjugating the somatostatin analogue TATE (Tyr3-octreotate) to sNIR, a novel cyanine dye that exhibits superior photostability, faster clearance, and reduced non-specific background retention compared to standard dyes like IRDye800. By specifically binding to SSTR2, which is highly overexpressed in meningiomas, SSTR2-sNIR enables real-time, high-contrast visualization of microscopic tumor remnants at the resection bed, potentially reducing the risk of tumor recurrence.
- Other names
- SSTR2-sNIRSSTR-2-sNIRSSTR 2-sNIRSSTR2-sNIR probeSSTR-2-sNIR probeSSTR 2-sNIR probeTATE-sNIR probe
02
Targets
SSTR2 (Somatostatin receptor type 2)
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