tauro-beta-muricholic acid

Tauro-beta-muricholic acid is a taurine-conjugated bile acid derived from beta-muricholic acid, occurring endogenously in rodents and at low levels in humans. It acts as a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 ≈ 40 μM), modulating bile acid metabolism and homeostasis. It also shows hepatoprotective effects in experimental cholestasis models, preventing liver and biliary injury caused by toxic bile salts. Frequent research purposes include experimental models of metabolic disease and liver pathophysiology[1][3][5][6][10].

Other names

tauro-β-muricholic acidtauro-b-muricholic acidtauro-b-muricholatebeta-tauromuricholic acidtauromuricholateN-(3alpha,6beta,7beta-trihydroxy-5beta-cholan-24-oyl)-taurine2-{[(3alpha,5beta,6beta,7beta)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino}ethane-1-sulfonic acidCHEBI:133057CAS 25696-60-0CAS25696-60-0CAS-25696-60-0