Drug intelligence / Profile preview

TauroLock-HEP100

Development stage
Phase 4
Lead developer
TauroPharm
Modality
Small Molecules
Administration
Percutaneous
01

Overview

TauroLock-HEP100 is a catheter lock solution developed by Tauropharm for use in central venous access devices, such as catheters and ports. It is a combination product containing taurolidine (1.35%), citrate (4%), and heparin (100 IU/mL). Taurolidine provides broad-spectrum antimicrobial activity against bacteria and fungi, including MRSA and VRE, and prevents biofilm formation. Citrate acts as an anticoagulant by chelating calcium ions, while heparin provides additional anticoagulation to maintain catheter patency. The solution is primarily used to prevent central line-associated bloodstream infections (CLABSIs) and catheter occlusions, particularly in pediatric oncology and hemodialysis settings. It is classified as a medical device/drug combination product.

Brand names
TauroLock-HEP100TauroLock-HEP-100TauroLock-HEP 100
Other names
taurolidine + citrate + heparin lock solution
02

Targets

ATIII (Antithrombin III)Microbial cell surfaces and biofilm matrixPF4 (Platelet factor 4)

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