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tauroselcholic acid (75Se)
- Development stage
- Unknown
- Lead developer
- General Electric
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral
01
Overview
Tauroselcholic acid (75Se), commonly known by the brand name SeHCAT, is a radiolabeled synthetic bile acid analog used as a diagnostic radiopharmaceutical. It is orally administered to investigate enterohepatic circulation, measure bile acid pool loss, and diagnose bile acid malabsorption (BAM) in patients presenting with chronic diarrhea, irritable bowel syndrome with diarrhea (IBS-D), or Crohn's disease. Chemically, it is a taurine-conjugated bile acid analog incorporating the gamma-emitting isotope selenium-75. Following oral administration, it behaves physiologically like natural conjugated bile acids, being absorbed in the terminal ileum via the apical sodium-dependent bile acid transporter (ASBT/SLC10A2) and excreted into the bile. Its retention in the body is measured over a seven-day period using a gamma camera, where a retention value of less than 15% indicates malabsorption.
- Brand names
- SeHCAT
- Other names
- 23-seleno-25-homotaurocholic acid75Se-tauroselcholic acidselenium homocholic acid taurineselenium-75 tauroselcholic acidselenium75 tauroselcholic acidselenium 75 tauroselcholic acidtauroselcholic [75selenium] acidtauroselcholic acid
02
Targets
SLC10A2 (Solute carrier family 10 member 2)
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