Drug intelligence / Profile preview

TAVT-45

Development stage
Phase 3
Lead developer
Tavanta Therapeutics
Modality
Small Molecules
Administration
Oral
01

Overview

TAVT-45 is an enhanced, novel oral granule formulation of abiraterone acetate developed for the treatment of metastatic prostate cancer, including both metastatic castration-resistant prostate cancer (mCRPC) and high-risk metastatic castration-sensitive prostate cancer (mCSPC). Unlike standard abiraterone acetate tablets (such as Zytiga), TAVT-45 is designed to be reconstituted in water or juice and consumed as an oral suspension, providing a more accessible option for patients with dysphagia or difficulty swallowing large tablets. Clinical studies have demonstrated that TAVT-45 achieves therapeutic equivalence to tablet formulations in terms of testosterone suppression and reduction in prostate-specific antigen levels, with a comparable safety profile. The improved bioavailability may allow effective dosing at lower amounts compared to traditional tablets[1][2][4][5][7].

Other names
abiraterone acetate granules for oral suspension
02

Targets

CYP17A1 (Steroid 17-alpha-hydroxylase/C17,20 lyase)

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