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taxane + anthracycline + eribulin + vinorelbine + capecitabine + carboplatin + UTD1 + platinum

Development stage
Preclinical
Lead developer
Fudan University
Modality
Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Intravenous, Oral
01

Overview

This is a multi-agent chemotherapy combination consisting of eight distinct drugs or drug classes commonly used in the treatment of various cancers, particularly breast cancer. The regimen includes: - Taxane (e.g., paclitaxel or docetaxel): Microtubule inhibitors that disrupt cell division. - Anthracycline (e.g., doxorubicin or epirubicin): DNA intercalators and topoisomerase II inhibitors causing DNA damage. - Eribulin: A synthetic microtubule dynamics inhibitor with a unique mechanism compared to taxanes, effective even in some taxane-resistant cancers[8]. - Vinorelbine: A vinca alkaloid that inhibits microtubule assembly, disrupting mitosis. - Capecitabine: An oral prodrug converted to 5-fluorouracil, inhibiting thymidylate synthase and interfering with DNA synthesis. - Carboplatin and Platinum (likely referring to platinum-based agents such as cisplatin): Alkylating-like agents causing crosslinking of DNA strands leading to apoptosis. - UTD1: No publicly available information; likely an investigational agent or code name not yet widely reported. Each component has a distinct mechanism targeting different aspects of cancer cell proliferation and survival. Such combinations are typically reserved for advanced/metastatic disease settings where multiple lines of therapy have failed, aiming for synergistic anti-tumor effects.

02

Targets

TOP2A (DNA topoisomerase II)TUBB (Tubulin (alpha and beta subunits))TS (Thymidylate synthase)dsDNA (Double-stranded DNA)DNA

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