taxanes + anthracyclines

Taxanes + anthracyclines refers to a combination chemotherapy regimen that includes drugs from the taxane class (such as paclitaxel or docetaxel) and the anthracycline class (such as doxorubicin or epirubicin). This combination is primarily used in the treatment of breast cancer, both in early-stage and advanced/metastatic settings. Taxanes disrupt microtubule function, inhibiting cell division, while anthracyclines intercalate into DNA and inhibit topoisomerase II, leading to DNA damage and apoptosis. The combination exploits their complementary mechanisms for enhanced antitumor activity[1][2][3]. Clinical studies have shown that this regimen improves response rates and progression-free survival compared to regimens using either drug class alone or with other agents[2][4]. However, it is associated with increased risks of hematological and gastrointestinal toxicities[4].

Other names

anthracycline and taxane combinationanthracycline-taxane regimen