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tazarotene + betamethasone dipropionate
- Development stage
- Phase 4
- Lead developer
- Chongqing Huapont Pharmaceutical
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
Lefusong is a topical combination therapy developed by Chongqing Huabang Pharmaceutical for the treatment of chronic plaque psoriasis. It contains tazarotene, a third-generation retinoid, and betamethasone dipropionate, a potent synthetic corticosteroid. Tazarotene acts as a selective agonist for retinoic acid receptors (RARs), specifically RAR-beta and RAR-gamma, which helps normalize keratinocyte differentiation and reduce epidermal hyperplasia. Betamethasone dipropionate acts as a glucocorticoid receptor agonist, providing anti-inflammatory, antipruritic, and immunosuppressive effects by inhibiting the release of inflammatory mediators. The combination is designed to enhance efficacy while potentially mitigating the irritation often associated with retinoid monotherapy.
- Brand names
- Lefusong
- Other names
- Tazarotene and Betamethasone Dipropionate Cream
02
Targets
GR (Glucocorticoid receptor)RARB (Retinoic acid receptor beta)RARG (Retinoic acid receptor gamma)
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