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TB511R

Development stage: Preclinical
Lead developer: Twinpig Biolab
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Peptide-Drug Conjugates → Peptide Conjugates → Peptides
Administration: Intravenous

Overview

TB511R is a preclinical theranostic peptide-drug conjugate (PDC) developed by TwinPigBio, designed to target the tumor microenvironment. It specifically targets the active form of CD18 (Integrin beta-2) expressed on Tumor-Associated Macrophages (TAMs), particularly M2-type macrophages. Utilizing the TAMpep™ - ESCLink™ platform, TB511R is conjugated to the radioisotope Lutetium-177 (177Lu). This configuration enables a theranostic approach, where the agent can be used for both diagnostic imaging and the delivery of targeted beta-radiation to eliminate immunosuppressive TAMs, thereby enhancing anti-tumor efficacy in various cancers.

Other names: TB511R-TwinPigBio-TAM (Active CD18)-Theranostics PDC-Lutetium-177 (177Lu) radioisotope payload-Cancer

Targets

ITGB2 (Complement receptor 4)

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