Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
TBA-7371
- Development stage
- Phase 2
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
TBA-7371 is an orally active small molecule and non-covalent inhibitor of decaprenylphosphoryl-beta-D-ribose oxidase (DprE1), an essential enzyme in the cell wall biosynthesis pathway of Mycobacterium tuberculosis. By inhibiting DprE1, TBA-7371 blocks the synthesis of arabinose in the bacterial cell wall, leading to structural defects and exerting a potent anti-tuberculosis effect. It belongs to the class of indoles and was identified through lead optimization studies as part of a novel series of 1,4-azaindole antibacterial compounds. The drug has demonstrated efficacy in preclinical rodent models and is currently under clinical evaluation for pulmonary tuberculosis. Its development involves both AstraZeneca and the Global Alliance for TB Drug Development (TB Alliance), with clinical trials also sponsored by Bill & Melinda Gates Medical Research Institute.
- Other names
- 1494675-86-3
02
Targets
PDE6 (Phosphodiesterase 6)DprE1 (Decaprenylphosphoryl-beta-D-ribose oxidase)
Beyond the preview
Go deeper on TBA-7371.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on TBA-7371.