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TBIO001 is a preclinical-stage small molecule therapeutic being developed by Tailor Biosciences for the treatment of solid tumors. It operates through a synthetic lethal mechanism of action, specifically targeting the cell cycle response pathway. The drug is designed to exploit chromosomal instability (CIN) in cancer cells. Its development is integrated with a companion diagnostic, TBIO001 CDx, which utilizes a CIN-based biomarker to identify patient populations most likely to benefit from the treatment. As of 2024, the program is in the candidate selection stage of preclinical development.
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