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TC Cream
- Development stage
- Phase 2
- Lead developer
- HiST Pharma
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
**TC Cream** is a topical botanical drug consisting of a total-coumarin fraction purified from *Cnidium monnieri* plant extract. It is being developed for psoriasis vulgaris by HiST Pharma and its Psoriasis Research Institute of Guangzhou subsidiary. The product was evaluated in the completed 88-patient Phase IIb PLANTCOAT-IIb study and is in the registered Phase III PLANTCOAT-III study for psoriasis vulgaris. Public abstracts describe it as having obtained an NDA approval for manufacturing in China; this should not be interpreted as U.S. marketing approval. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03372811))
- Brand names
- TC Cream
- Other names
- total coumarin creambotanical total coumarin cream
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