Drug intelligence / Profile preview

TCAP

Development stage
Preclinical
Modality
Peptides
01

Overview

TCAP refers to the **teneurin C-terminal associated peptide** or **TCAP-1**, a bioactive neuropeptide sequence found at the C-terminus of the teneurin protein family. TCAP-1 has been investigated for its potential neuromodulatory, anxiolytic, and behavioral effects, such as reducing stress- and addiction-related behaviors. In preclinical and patent literature, TCAP-1 is examined for possible therapeutic use in neuropsychiatric and addictive disorders, including opioid addiction. The mechanism of action is not fully defined but is believed to involve modulation of corticotropin-releasing factor signaling and regulation of glutamatergic and opioid-related neurocircuitry[2].

Other names
teneurin C-terminal associated peptideteneurin C-terminal associated peptide-1TCAP-1TCAP1TCAP 1
02

Targets

CRHR (Corticotropin-releasing hormone receptors)LPHN (Latrophilin receptor family)

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