Drug intelligence / Profile preview

TCB008

Development stage
Phase 2
Lead developer
TC BioPharm
Modality
Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration
Intravenous
01

Overview

TCB008 (also known as OmnImmune) is an investigational allogeneic unmodified cell therapy composed of activated and expanded gamma delta (γδ) T cells derived from healthy donors. These CD3+ lymphocytes express the Vγ9Vδ2 T-cell receptor and are expanded ex vivo before being purified and formulated for infusion. The therapy is designed to boost the immune response in patients with relapsed or refractory acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS)/AML by leveraging the innate and adaptive immune properties of γδ T cells, which can distinguish between healthy and diseased tissue. Developed by TC BioPharm, this product is currently under clinical investigation in phase 1b/2 trials for AML/MDS[1][3][5][7].

Brand names
OmnImmune
Other names
tcb008tcb-008tcb 008
02

Targets

BTN3A1 (Butyrophilin 3A1/2A1 complex)MICB (Major histocompatibility complex class i-related protein B)NECTIN2 (Nectin cell adhesion molecule 2)ULBP (UL16-binding protein)

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