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tCellVax
- Development stage
- Preclinical
- Lead developer
- Regen BioPharma
- Modality
- Chemically Modified siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Bone Marrow HSCs → Hematopoietic Stem Cells → Adult Stem Cells → Stem Cell Therapies → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Conjugated siRNA → Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
tCellVax is a cell-based immunotherapy developed for the treatment of solid tumors. It works by extracting immune cells from a patient and using ex vivo siRNA technology to silence the NR2F6 gene in these cells. The silencing of NR2F6, an intracellular immune checkpoint, is intended to activate the patient's immune system against cancer. This approach aims to enhance anti-tumor immunity by removing inhibitory signals that limit T-cell activity. The therapy utilizes proprietary methods involving gene silencing through siRNA and may also incorporate modified mRNA technologies[1][2][3][4].
02
Targets
NR2F6 (Nuclear receptor subfamily 2 group F member 6)
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