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TCM allogeneic human central memory T cells
- Development stage
- Phase 2
- Lead developer
- University Hospital Würzburg
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
TCM allogeneic human central memory T cells is an investigational allogeneic cell therapy consisting of purified, non-expanded, and cryopreserved donor-derived central memory T cells (TCM). Developed by Wuerzburg University Hospital, the therapy is administered prophylactically to patients with Acute Myeloid Leukemia (AML) or Myelodysplastic Syndrome (MDS) following T-cell depleted, HLA-matched allogeneic hematopoietic stem cell transplantation (alloHSCT). The primary objective is to facilitate rapid and sustained immune reconstitution, providing graft-versus-leukemia (GVL) activity and protection against infectious complications while potentially minimizing the risk of graft-versus-host disease (GVHD) typically associated with unselected donor lymphocyte infusions. The product is currently being evaluated in the PACT trial (NCT02758223).
- Other names
- TCM allogeneic humane central memory T cells, cryopreserveddonor-derived central memory T lymphocytesTCM
02
Targets
pHLA (Leukemia-associated peptide-human leukocyte antigen complex)MiHA (Minor histocompatibility antigen)pMHC (Peptide-MHC complex family)Alloreactive and cross-reactive self peptide–HLA complexes
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