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TCM core prescription
- Development stage
- Unknown
- Lead developer
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral, Nasal Feeding
01
Overview
TCM core prescription refers to a specific multi-herb Traditional Chinese Medicine (TCM) decoction developed for the treatment of sepsis-induced cardiomyopathy (SIC). In the context of clinical research conducted by the Guangdong Provincial Hospital of Chinese Medicine, this prescription consists of seven traditional herbs: Huangqi (Astragalus membranaceus), Danshen (Salvia miltiorrhiza), Shu Fuzi (Aconitum carmichaelii), Danggui (Angelica sinensis), Chuanxiong (Ligusticum striatum), Fuling (Poria cocos), and Dahuang (Rheum palmatum). The formula is designed to address the complex pathophysiology of SIC, which involves systemic inflammation, oxidative stress, and myocardial depression. Its mechanism of action is multi-targeted, typically involving the modulation of inflammatory cytokines, reduction of myocardial injury, and improvement of microcirculation. The decoction is administered as an adjunct to conventional Western medical treatment, often via oral or nasal feeding.
- Other names
- 核心处方Core prescription for sepsis-induced cardiomyopathy
02
Targets
IL-6 (Interleukin 6)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CASP3 (Caspase-3)
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