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TCM herbal lung granules

Development stage: Phase 1
Lead developer: Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

TCM herbal lung granules is an investigational, lung-directed traditional Chinese medicine (TCM) formulation prepared as oral granules. It is designed to target the respiratory system for the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). In clinical trials, such as the four-arm parallel interventional study ChiCTR-TRC-09000533 sponsored by Dongzhimen Hospital Affiliated to Beijing University of Traditional Chinese Medicine, this formulation is evaluated alongside intestine-directed TCM granules and combined lung-intestine TCM granules (such as the Xuan Bai Cheng Qi formula) to assess its therapeutic efficacy on pulmonary function, TCM symptom scores, blood gas analysis, and exercise tolerance in patients with AECOPD.

Other names: lung-directed traditional Chinese medicine granules

Targets

EGFR (Epidermal growth factor receptor)ICAM1 (Intercellular Adhesion Molecule 1)IFNG (Interferon gamma)IL-6 (Interleukin 6)MAPK14 (p38 mitogen-activated protein kinase alpha)MAPK3 (Mitogen-activated protein kinase 1)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)RELA (Nuclear Factor Kappa B Subunit p65)SRC (Proto-oncogene tyrosine-protein kinase Src)STAT3 (Signal Transducer and Activator of Transcription 3)TLR4 (Toll-like receptor 4)VEGFA (Vascular endothelial growth factor A)

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