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A 5% tea tree oil (Melaleuca alternifolia) gel formulation developed by Alexandria University for the treatment of stage 2 (moderate) periodontitis. It is designed for intrapocket application as an adjunctive therapy to scaling and root planing (SRP). The formulation utilizes Carbopol 940 as a gelling agent and exhibits broad-spectrum antimicrobial, anti-inflammatory, antifungal, antiviral, and antioxidant properties. Clinical studies have demonstrated its efficacy in improving clinical parameters and reducing biochemical markers such as matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid.
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