Drug intelligence / Profile preview

tea tree oil gel

Development stage
Phase 4
Lead developer
Ain Shams University
Modality
Small Molecules, Hydrogel Systems → Drug Delivery Systems
Administration
Topical
01

Overview

Tea tree oil (TTO) gel is a natural phytotherapy modality being investigated by Ain Shams University as a locally delivered adjunct to non-surgical periodontal debridement for the treatment of localized periodontitis. Extracted from the *Melaleuca alternifolia* plant, the oil contains active components such as terpinen-4-ol and 1,8-cineole, which provide antimicrobial, anti-inflammatory, and antioxidant properties. In clinical studies, a 5% TTO gel formulation is applied directly into periodontal pockets to reduce the levels of periodontal pathogens and inflammatory mediators (such as TNF-α, IL-1β, and PGE2), thereby facilitating tissue repair and improving clinical outcomes like pocket depth and attachment level.

Other names
Melaleuca alternifolia oiltea tree oilTTOMelaleuca alternifolia oil gel
02

Targets

IL1B (Interleukin-1 beta)PGE2 (Prostaglandin E2)TLR2 (Toll-like Receptor 2)TNFA (Tumor necrosis factor alpha (soluble))

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