Drug intelligence / Profile preview

tea tree oil gel

Development stage
Phase 4
Lead developer
Ain Shams University
Modality
Hydrogel Systems → Drug Delivery Systems, Small Molecules
Administration
Topical
01

Overview

Tea tree oil (TTO) gel is a natural phytotherapy modality being investigated by Ain Shams University as a locally delivered adjunct to non-surgical periodontal debridement for the treatment of localized periodontitis. Extracted from the *Melaleuca alternifolia* plant, the oil contains active components such as terpinen-4-ol and 1,8-cineole, which provide antimicrobial, anti-inflammatory, and antioxidant properties. In clinical studies, a 5% TTO gel formulation is applied directly into periodontal pockets to reduce the levels of periodontal pathogens and inflammatory mediators (such as TNF-α, IL-1β, and PGE2), thereby facilitating tissue repair and improving clinical outcomes like pocket depth and attachment level.

Other names
Melaleuca alternifolia oiltea tree oilTTOMelaleuca alternifolia oil gel
02

Targets

PGE2 (Prostaglandin E2)TLR2 (Toll-like Receptor 2)TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)

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