Drug intelligence / Profile preview

tea tree oil vagitories

Development stage
Unknown
Lead developer
University of Sarajevo
Modality
Small Molecules
Administration
Vaginal
01

Overview

Tea tree oil vagitories are an investigational herbal formulation developed by the University of Sarajevo for the treatment of non-specific vaginitis. The formulation is a plant-based preparation that combines tea tree oil (Melaleuca alternifolia) with other herbal extracts, including St. John's wort (Hypericum perforatum), chamomile, calendula, yarrow, and shepherd's purse. The active components, particularly terpinen-4-ol from tea tree oil, provide antimicrobial, anti-inflammatory, and wound-healing properties. The formulation targets pathogenic bacteria and inflammatory mediators associated with vaginal infections. In a Phase 4 randomized controlled trial (NCT04558697), these vagitories demonstrated superior efficacy in improving clinical symptoms of vaginitis compared to single-herb or probiotic alternatives.

Other names
tea tree oil-University of Sarajevo-non-specific vaginitisHerbal Vagitories for Non-Specific VaginitisTea tree oil-based vagitories
02

Targets

TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)

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