Drug intelligence / Profile preview

tecemotide + hormonal treatment

Development stage
Preclinical
Lead developer
Merck KGaA
Modality
Recombinant Proteins and Enzymes, Small Molecules, Vaccines & Immunotherapeutics
Administration
Subcutaneous (tecemotide), Oral Or Injection (hormonal Agents; E.g., Oral For Aromatase Inhibitors Like Letrozole; Injection For GnRH Analogs)
01

Overview

Tecemotide + hormonal treatment is an investigational combination therapy consisting of tecemotide (L-BLP25), a synthetic lipopeptide cancer vaccine targeting the tumor-associated antigen mucin-1 (MUC1), administered alongside standard hormonal (endocrine) therapies. Tecemotide is designed to stimulate a T-cell mediated immune response against MUC1-expressing tumor cells. The combination has been studied primarily in hormone-sensitive cancers such as breast and prostate cancer, aiming to enhance anti-tumor efficacy by combining immunotherapy with endocrine blockade. Tecemotide was developed by Merck KGaA/EMD Serono and has been evaluated in multiple phase II and III trials for various solid tumors including non-small cell lung cancer, breast cancer, and prostate cancer[1][2][3][6][7].

Other names
BLP25 liposome vaccineBLP-25 liposome vaccineBLP 25 liposome vaccineMUC1 vaccine + hormonal therapy
02

Targets

CYP19A1 (Aromatase)TLR4 (Toll-like receptor 4)

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