Drug intelligence / Profile preview

technetium (99mTc) albumin aggregated

Development stage
Unknown
Lead developer
Bristol Myers Squibb
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals, Recombinant Proteins and Enzymes
Administration
Intravenous, Intraperitoneal
01

Overview

Technetium (99mTc) albumin aggregated (commonly referred to as technetium-99m-labeled macroaggregated albumin or Tc-99m MAA) is a sterile, non-pyrogenic, radiolabeled diagnostic agent used in nuclear medicine. It consists of human serum albumin (HSA) aggregated into macroparticles and labeled with the gamma-emitting radionuclide technetium-99m (Tc-99m). Following intravenous administration, the macroaggregated particles mechanically lodge within the terminal precapillary arterioles and capillaries of the lungs during their first pass through the pulmonary circulation. This temporary microembolization allows for the visualization of pulmonary perfusion via single-photon emission computed tomography (SPECT) or planar scintigraphy, making it a standard tool for diagnosing pulmonary embolism and evaluating lung perfusion. Additionally, Tc-99m MAA can be administered intraperitoneally to assess the patency of peritoneovenous (LeVeen) shunts or to diagnose pleuroperitoneal communication in peritoneal dialysis patients.

Brand names
DraxImage MAAMacrotecMPI MAAPulmocisPulmolitePulmotech MAATechnescan MAA
Other names
99mTc-MAA99mTc-labeled macroaggregated albuminTc 99m-labeled MAATc99m-labeled MAATc-99m-labeled MAATc 99m-labeled macroaggregated albuminTc99m-labeled macroaggregated albuminTc-99m-labeled macroaggregated albuminTc-99m MAATc99m MAATc 99m MAAtechnetium (99mTc) macrosalbtechnetium Tc 99m aggregated albumintechnetium Tc 99m albumin aggregatedtechnetium-99m macroaggregated albumintechnetium99m macroaggregated albumintechnetium 99m macroaggregated albumintechnetium-99m-labeled albumin macroaggregatestechnetium99m-labeled albumin macroaggregatestechnetium 99m-labeled albumin macroaggregatestechnetium-99m-labeled macroaggregated albumintechnetium99m-labeled macroaggregated albumintechnetium 99m-labeled macroaggregated albumin

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