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Drug intelligence / Profile preview
technetium (99mtc) oxidronate
- Development stage
- Unknown
- Lead developer
- Curium
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
Technetium (99mTc) oxidronate (commonly referred to as technetium-99m hydroxyphosphonate, technetium-99m hydroxymethylene diphosphonate, or Tc-99m HDP) is a diagnostic radiopharmaceutical agent used in bone scintigraphy (skeletal imaging). It consists of a complex of the metastable radionuclide technetium-99m with oxidronate (hydroxymethylene diphosphonate), a bisphosphonate ligand. Following intravenous administration, the complex rapidly distributes throughout the extracellular space and preferentially localizes in areas of active bone formation or altered osteogenesis by chemisorption onto hydroxyapatite crystals. This allows for high-sensitivity visualization of bone pathologies, including metastatic bone disease, osteomyelitis, fractures, avascular necrosis, and prosthetic joint evaluation, using gamma camera imaging.
- Brand names
- Osteoscan-HDPTechnescan HDP
- Other names
- 99mTc-HDP99mTc-HMDPTc-99m HDPTc99m HDPTc 99m HDPTc-99m HMDPTc99m HMDPTc 99m HMDPtechnetium tc 99m hydroxymethylene diphosphonatetechnetium tc 99m oxidronatetechnetium tc-99m oxidronatetechnetium-99m hydroxyphosphonatetechnetium99m hydroxyphosphonatetechnetium 99m hydroxyphosphonatetechnetium-99m hydroxymethylene diphosphonatetechnetium99m hydroxymethylene diphosphonatetechnetium 99m hydroxymethylene diphosphonatetechnetium-99m oxidronatetechnetium99m oxidronatetechnetium 99m oxidronate
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