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technetium-99m-human serum albumin-indocyanine green

Development stage: Phase 1
Lead developer: Korea University Guro Hospital
Modality: Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems
Administration: Intradermal, Subcutaneous, Peritumoral, Intracervical

Overview

Technetium-99m-human serum albumin-indocyanine green is an investigational **hybrid radioactive-fluorescent sentinel lymph node mapping tracer** developed for intraoperative use in lung cancer surgery. It combines technetium-99m labeling for preoperative and intraoperative gamma-based localization with indocyanine green near-infrared fluorescence for real-time optical visualization. The human serum albumin-based carrier is intended to facilitate lymphatic drainage and retention in sentinel lymph nodes, enabling dual-modality identification of nodes that may contain metastatic disease.

Other names: 99mTc-HSA-ICG99mTc-MSA-ICGTc-MSA-ICG

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